Endocrine Abstracts

Acromegaly alters elasticity, structure and function of the respiratory system and respiratory disorders constitute 25% of all deaths recorded in acromegalic patients. Respiratory mortality is three fold higher than in normal subjects. However, respiratory dysfunction in acromegaly has seldom been investigated.We aimed to evaluate the extent of pulmonary dysfunction in acromegalic patients with respiratory function tests (RFT). Sixty one acromegalic pati...

Aim: The present study aimed to investigate the relationship of visceral fat accumulation with the existence of the carotid plaque in ischemic stroke patients.Materials and methods: Seventy patients (37 male, 33 female) with acute ischemic stroke were enrolled in the study. The carotid IMT and the existence of carotid plaque of the patients were evaluated by high resolution ultrasonography with a 7.5 MHz linear superficial array probe in B-mode. The abdo...

A 49-year-old man with history of nodular goitre operation was referred to our clinic because of MTC in postoperative pathology. He had hypertension, postoperative hypothyroidism, no family history of thyroid carcinoma and sudden death. Laboratuary investigations showed high level of calcitonin (C) (763 pg/ml; normal<150), Carcino embryogenic antigen (CEA) (175 ng/ml; normal<2.5), normal thyroid function tests, parathormone, urinary catecholamines. Ser904 polymorphism ...

Cardiovascular diasease (CV) is the leading cause of mortality in acromegalic patients. Although acromegalic cardiomyopathy has been extensively investigated, there is a lack of data about atherosclerosis in acromegaly.We aimed to the evaluate the extent of carotid atherosclerosis with various CV biomarkers in acromegaly. Sixty-one acromegalic patients and 21 age and sex matched healthy controls were included. We measured carotid intima media thickness (...

Aim: Comparison of the parameters of obesity with the newly-defined adipocytokines in females applying to our clinic for obesity.Method: Demographical data of 36 obese females were determined. Cases were classified as obese and morbid obese according to BMI values. Biochemical parameters were measured for all the cases. Thicknesses of subcutaneous and visceral fatty tissues were measured on ultrasonography. Statistical significances were evaluated by app...

Introduction: Vitamin D (Vit D) receptors have been shown in extra skeletal tissues. Vit D deficiency plays a role in the development of many malignant, chronic inflammatory, autoimmune and metabolic diseases. Our aim was to evaluate the effect of Vit D replacement therapy on insulin sensitivity, endothelial function and oxidative stress in Vit D deficient subjects.Material-method: Serum 25(OH) D levels of 74 volunteer-healthy subjects (22.7±2.7) we...

Hypothyroidism is associated with increased cardiovascular mortality. Epicardial fat thickness (EFT) has been found to be correlated with visceral fat accumulation and is thought to be a novel cardiovascular risk factor. The aim of this study was to determine EFT and its relationship with carotid intima media thickness (CIMT) and flow-mediated vasodilation (FMD) in subclinical and overt hypothyroid patients.Ten patients with overt (Group H) (42.2±15...

Aim: To determine how serum procalcitonin (PCT) levels are affected in diabetic and diabetic nephropathic patients, it is important to determine whether PCT is indicative of an inflammation in these patients.Materials and methods: The study included 175 patients (75 diabetic nephropathy (group 1), 75 diabetic (group 2) and 25 non-diabetic nephropathy (group 3)) and 75 healthy volunteers. Serum and urine creatinine, serum high sensitive C- reactive protei...

The efficacy of peritoneal dialysis (PD) is closely related to the status of the peritoneum. Long-term PD leads to structural and functional changes in the peritoneum and affects dialysis adequacy. Also high-glucose content of dialysate accelerates peritoneal fibrosis. It is reported that ultrasonography (USG) reflects parietal peritoneal membrane thickness and PD duration is related with peritoneal thickness. This study aimed to evaluate peritoneal thickness with USG in PD pa...

Aim: Overt/subclinic hypothyroidism and hyperthyroidism are known to be associated with cardiovascular risks. There have been no studies evaluating the relationship between nodule presence and arterial stiffness in individuals with euthyroid nodular goitre. Our aim in this study is to demonstrate whether nodule presence and nodule stiffness affect arterial stiffness in individuals with euthyroid nodular goitre by using pulse wave analysis (PWA).Materials...